Comparison between the ages for the genders (after controlling for type)

Questions

  • What are the differences between the ages for the different genders?
  • Do we observe the same changes as globally?

Age effect - General Questions

  • What are the differences between the ages?
  • Which genes and pathways are differentially expressed between 8w and 52w, between 52w and 104w, between 8w and 104w? Are they the same? Is there a gradient?
  • Are they different for the two genders?
  • Are they different for the two types?

Loads

Libraries and functions

Allowing multi-threading with up to 4 threads.
[1] "preparing gene to GO mapping data..."
[1] "preparing IC data..."
[1] "preparing gene to GO mapping data..."
[1] "preparing IC data..."
[1] "preparing gene to GO mapping data..."
[1] "preparing IC data..."

Data

Stats

Wald padj < 0.05LFC > 0 (Wald padj < 0.05)LFC < 0 (Wald padj < 0.05)
52w VS 8w (F)227812651013
52w VS 8w (M) 427 261 166
104w VS 8w (F)18411074 767
104w VS 8w (M)370619251781
104w VS 52w (F) 290 169 121
104w VS 52w (M)387219741898

Differentially expressed genes

Warning message in grep(txdbPattern, installedPackages):
“argument 'pattern' has length > 1 and only the first element will be used”Warning message in pcls(G):
“initial point very close to some inequality constraints”Warning message in grep(txdbPattern, installedPackages):
“argument 'pattern' has length > 1 and only the first element will be used”Warning message in pcls(G):
“initial point very close to some inequality constraints”Warning message in grep(txdbPattern, installedPackages):
“argument 'pattern' has length > 1 and only the first element will be used”Warning message in pcls(G):
“initial point very close to some inequality constraints”Warning message in grep(txdbPattern, installedPackages):
“argument 'pattern' has length > 1 and only the first element will be used”Warning message in pcls(G):
“initial point very close to some inequality constraints”Warning message in grep(txdbPattern, installedPackages):
“argument 'pattern' has length > 1 and only the first element will be used”Warning message in pcls(G):
“initial point very close to some inequality constraints”Warning message in grep(txdbPattern, installedPackages):
“argument 'pattern' has length > 1 and only the first element will be used”Warning message in pcls(G):
“initial point very close to some inequality constraints”

Counts

52w != 8w or 104w != 8w or 104w != 52w for F with abs(FC) > 2

52w != 8w or 104w != 8w or 104w != 52w for M with abs(FC) > 2

Genes with 52w != 8w or 104w != 8w or 104w != 52w for M or F and at least one FC > 2

Comparison of the numbers per types

Differentially expressed genes

Some explanation (specially for the gender difference in microglia aging)

Differentially more expressed genes

Differentially less expressed genes

DEG into gene co-expression network

  • White: up-regulated
  • Black: down-regulated
Comp Male Female
52w vs 8w
104w vs 52w
104w vs 8w

GO analysis

Biological process

Dot-plot with the most over-represented BP GO (20 most significant p-values for the different comparison)

Network based on description similarity

Comp Male Female
52w vs 8w
104w vs 52w
104w vs 8w

52w VS 8w (F)

<!DOCTYPE html>

52w VS 8w (M)

<!DOCTYPE html>

104w VS 52w (F)

<!DOCTYPE html>

104w VS 52w (M)

<!DOCTYPE html>

Cellular components

Dot-plot with the most over-represented CC GO (20 most significant p-values for the different comparison)

Comp Female Male
52w vs 8w
104w vs 52w
104w vs 8w

Molecular functions

Dot-plot with the most over-represented MF GO (20 most significant p-values for the different comparison)

Comp Female Male
52w vs 8w
104w vs 52w
104w vs 8w

KEGG pathways

[1] "Note: 83 of 6572 unique input IDs unmapped."
[1] "Note: 83 of 6572 unique input IDs unmapped."
[1] "Note: 83 of 6572 unique input IDs unmapped."
[1] "Note: 83 of 6572 unique input IDs unmapped."
[1] "Note: 83 of 6572 unique input IDs unmapped."
[1] "Note: 83 of 6572 unique input IDs unmapped."
[1] "Note: 83 of 6572 unique input IDs unmapped."

Warning message in file.rename(from = paste("mmu", cat, ".pathview.multi.png", sep = ""), :
“cannot rename file 'mmu00533.pathview.multi.png' to '../results/dge/age-effect/age_gender/over_repr_kegg/mmu00533.pathview.multi.png', reason 'No such file or directory'”
[1] "Note: 83 of 6572 unique input IDs unmapped."

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“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”
[1] "Note: 83 of 6572 unique input IDs unmapped."
[1] "Note: 83 of 6572 unique input IDs unmapped."
[1] "Note: 83 of 6572 unique input IDs unmapped."
[1] "Note: 83 of 6572 unique input IDs unmapped."
[1] "Note: 83 of 6572 unique input IDs unmapped."

[1] "Note: 83 of 6572 unique input IDs unmapped."
[1] "Note: 83 of 6572 unique input IDs unmapped."
[1] "Note: 83 of 6572 unique input IDs unmapped."

Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”Warning message in structure(x$children, class = "XMLNodeList"):
“Calling 'structure(NULL, *)' is deprecated, as NULL cannot have attributes.
  Consider 'structure(list(), *)' instead.”

Gender differences in aging

Question: Is there differences in aging between gender? Is there really a delay for some genes in male?

52w vs 8w for F 52w vs 8w for M 104w vs 52w for F 104w vs 52w for M Gene number
Set 1 != == == != 729
Set 2 == != != == 9
Gene number
Set 1729
Set 2 9

Genes with differential expression delayed in male

Genes (set 1):

  • Differentially expressed between 52w and 8w in F
  • Not differentially expressed between 104w and 52w in F
  • Not differentially expressed between 52w and 8w in M
  • Differentially expressed between 104w and 52w in M
  • No criteria for 104w vs 8w in both F and M

52w VS 8w (F) > 0 and 104w VS 52w (M) > 0

[1] 186

	Pearson's product-moment correlation

data:  mat[, 1] and mat[, 2]
t = 34.483, df = 184, p-value < 2.2e-16
alternative hypothesis: true correlation is not equal to 0
95 percent confidence interval:
 0.9083259 0.9475915
sample estimates:
      cor 
0.9305874

52w VS 8w (F) > 0 and 104w VS 52w (M) < 0

[1] 136

	Pearson's product-moment correlation

data:  mat[, 1] and mat[, 2]
t = -26.39, df = 134, p-value < 2.2e-16
alternative hypothesis: true correlation is not equal to 0
95 percent confidence interval:
 -0.9393075 -0.8836611
sample estimates:
       cor 
-0.9157734

52w VS 8w (F) < 0 and 104w VS 52w (M) > 0

[1] 267

	Pearson's product-moment correlation

data:  mat[, 1] and mat[, 2]
t = -8.3658, df = 265, p-value = 3.45e-15
alternative hypothesis: true correlation is not equal to 0
95 percent confidence interval:
 -0.5471083 -0.3566042
sample estimates:
       cor 
-0.4570828

52w VS 8w (F) < 0 and 104w VS 52w (M) < 0

[1] 140

	Pearson's product-moment correlation

data:  mat[, 1] and mat[, 2]
t = 16.17, df = 138, p-value < 2.2e-16
alternative hypothesis: true correlation is not equal to 0
95 percent confidence interval:
 0.7428457 0.8595714
sample estimates:
      cor 
0.8090422

Summary

Comp 52w VS 8w (F) < 0 52w VS 8w (F) > 0
104w VS 52w (M) > 0
104w VS 52w (M) < 0
117
29
64
17

Genes with differential expression delayed in female

Genes (set 2):

  • Not differentially expressed between 52w and 8w in F
  • Differentially expressed between 104w and 52w in F
  • Differentially expressed between 52w and 8w in M
  • Not differentially expressed between 104w and 52w in M
  • No criteria for 104w vs 8w in both F and M
0